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SID-Matriptase |
Also Known As: suppression of tumorigenicity 14, ST14,
membrane-type serine protease, MTSP1,
epithin,
MT-SP1, MTSP-1, SNC19, and PRSS14
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The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. Predicted molecular weight of full protein is 95kDa. [provided by RefSeq]
Antibodies to KLK8:
1G11E10D11
1G3D3B12 |
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